Article 13 September Open Access. Transparent conducting oxides are wide bandgap conductors that have found a range of applications in optoelectronic devices. In this study, Hosono and colleagues fabricate the first transparent conducting oxide based on germanium. Understanding the genetics and physiology of domesticated species is important for crop improvement.
By studying natural variation and the phenotypic traits of diverse accessions of rice, Zhao et al. Article 13 September Cellular senescence is characterized by the cessation of cell growth and the expression of the p16 protein. In this study, inhibition or loss of p, a histone acetyltransferase, is shown to result in senescence that occurs independently of p16 and is associated with histone hypoacetylation and altered replication timing. Protein microarrays are useful both in basic research and also in disease monitoring and diagnosis, but their dynamic range is limited.
By using plasmonic gold substrates with near-infrared fluorescent enhancement, Tabakman et al. It is unclear whether the Fermi surface in the normal state of underdoped cuprates is ambipolar or solely nodal. The paradigm of reservoir computing shows that, like the human brain, complex networks can perform efficient information processing. Here, a simple delay dynamical system is demonstrated that can efficiently perform computations capable of replacing a complex network in reservoir computing. Plasmonic nanostructures can be used to manipulate objects larger than the wavelength of light but create thermal heating.
In this work, the trapping and controlled rotation of nanoparticles is demonstrated using a plasmonic nanotweezer with a heat sink, predicting a reduction in heating compared with previous designs. Recent technological advances have allowed the expansion of spermatogonial stem cells in vitro ; however, in vivo conditions are required for the full differentiation of the cells. In this study, an in vitro organ culture system is developed that allows the differentiation of the germ cells in the laboratory. Article 06 September Hydrogels have a variety of applications including tissue engineering and controlled drug delivery.
Here, liquid-crystal hydrogels are developed which transform into a fluid solution upon cooling; cells can be encapsulated in the gel at room temperature, then released at physiological temperatures. Quadrupoles have many engineering applications, but experimental observations of fluidic multipoles have not been reported. This study presents an experimental two-dimensional microfluidic quadrupole, a theoretical analysis consistent with observations, and a first application as a channel-free floating gradient generator.
In response to antigens, B cells proliferate and form germinal centres before differentiating into memory B cells or long-lived plasma cells. Here, a culture method is used to expand B cells in vitro, with the ability to shift the fate of the cells between memory B cells and long-lived plasma cells. Property coupling by heteroepitaxy is severely limited in material combinations with highly dissimilar bonding. This report presents a chemical boundary condition methodology to actively engineer two-dimensional film growth in such systems that otherwise collapse into island formation and rough morphologies.
Article 06 September Open Access. The measurement of the total cross-section of proton—proton collisions is of fundamental importance for particle physics.
Here, the first measurement of the inelastic cross-section is presented for proton—proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider. Group B Streptococcus causes meningitis in newborn infants but how the bacterium crosses the blood-brain barrier is unknown. Here, the bacterial pili adhesion molecule, PilA, is shown to bind to collagen and promote binding of the bacteria to integrins expressed on the blood-brain endothelium.
Article 30 August Open Access.
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The appearance of a new intron that splits an exon without disrupting the corresponding peptide sequence is a rare event in vertebrate genomes. Hellsten et al. Cell-penetrating peptides can deliver molecular cargoes into living cells, and cross biological membranes by transduction—a non-endocytic mechanism. Here, the transduction efficiency of cyclic arginine-rich peptides is shown to be higher than that of more flexible linear peptides.
Many mammals are born with an immature intestinal epithelium, which adapts to a changing diet during the weaning period.
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Muncan et al. Article 30 August Autostereoscopic three-dimensional displays allow the perception of depth, by presenting offset images to the left and right eye, without the need for specialized glasses. Yoon et al propose a Lucius microprism array to control the directionality and intensity of light in three-dimensional displays.
Various methods have been investigated to locally control atmospheric precipitation. Photodetection is believed to be among the most promising potential applications for graphene. Here, by combining graphene with plasmonic nanostructures, the efficiency of graphene-based photodetectors is increased by up to two orders of magnitude. The assembly mechanisms of heteromeric ion channels are poorly understood. Using a range of techniques, Shuart et al. Article 23 August Modern female horses are genetically diverse but male horses are relatively homogenous. Lippold et al. Advanced search. Skip to main content.
Articles in All Article 11 October Bottom-up synthesis of finite models of helical n,m -single-wall carbon nanotubes Hoop-shaped aromatic hydrocarbons can be considered as finite models of single-wall carbon nanotubes. Article 11 October Osmium evidence for synchronicity between a rise in atmospheric oxygen and Palaeoproterozoic deglaciation The Early Palaeoproterozoic saw glaciations and a rise in atmospheric oxygen, but the link between these two changes is poorly understood.
Article 11 October The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle The Golgi membrane is fragmented during mitosis and is subsequently fused following cell division and this process is known to be controlled by ubiquitination. Article 11 October A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death Radiomitigating compounds could be used to protect against ionizing radiation.
Article 11 October Electrosensory ampullary organs are derived from lateral line placodes in bony fishes Ampullary organs are involved in electroreception, but whether these are derived from placodes, thickened ectoderm, is unclear. Article 11 October Single-molecule fluorescence spectroscopy maps the folding landscape of a large protein The folding of multidomain proteins can involve metastable intermediate states. Article 11 October Selective fluorescent probes for live-cell monitoring of sulphide Molecular probes that can detect aqueous sulphides could help to elucidate their roles in biological signalling.
Article 11 October Open Access Travelling and splitting of a wave of hedgehog expression involved in spider-head segmentation During development, waves of gene expression are required for segmentation of the body axis. Article 11 October Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells The fusion of satellite cells to muscle fibres during adult life is required for both muscle growth and regeneration but it is unknown whether non-muscle cells contribute to this process.
Article 11 October NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers In non-NMDA glutamate receptors, intersubunit contacts within agonist binding domains affect functional desensitization. Article 04 October Open Access Designing attractive models via automated identification of chaotic and oscillatory dynamical regimes Modelling of chaos and oscillations is usually done indirectly and quantitatively by fitting models to a finite number of data-points.
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Article 04 October Reprogramming within hours following nuclear transfer into mouse but not human zygotes The generation of human cell lines using somatic cell nuclear transfer has been difficult to achieve. Article 04 October Spin coupling and relaxation inside molecule—metal contacts The ability to control the charge and spin of single molecules at metal interfaces underpins the concept of molecular electronics. Article 04 October Phosphatidylinositol 4,5 bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells The role of phosphatidylinositol 4,5 bisphosphate in exocytosis is unclear.
Article 27 September Open Access Role of mid-gap states in charge transport and photoconductivity in semiconductor nanocrystal films Nanocrystals are used in light-emitting diodes and solar cells, but their charge transport in films is unclear. Article 27 September Open Access Identification and microbial production of a terpene-based advanced biofuel Advanced biofuels with comparable properties to petroleum-based fuels could be microbially produced from lignocellulosic biomass.
Article 27 September Room temperature magnetic materials from nanostructured diblock copolymers Simple routes to self-assembling magnetic materials are elusive. Article 27 September Open Access The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke The risk factors associated with both ischemic and haemorrhagic stroke are not fully understood. Article 20 September A chloroplast envelope-bound PHD transcription factor mediates chloroplast signals to the nucleus Retrograde chloroplast signals are essential in coordinating nuclear gene expression, but the mechanism that relays chloroplast signals to the nucleus remains elusive.
Article 20 September Open Access A bimetallic nanoantenna for directional colour routing Plasmon resonances occur as collective excitations of surface electrons in noble metal nanoparticles. Article 20 September Open Access An energy transduction mechanism used in bacterial flagellar type III protein export A bacterial export gate complex transports flagellar proteins across the cytoplasmic membrane, but the mechanism of this process is unclear.
Article 20 September Open Access Detecting inertial effects with airborne matter-wave interferometry Inertial sensors using atom interferometry have applications in geophysics, navigation- and space-based tests of fundamental physics. Article 20 September Open Access High pressure route to generate magnetic monopole dimers in spin ice Spin ices are magnetic materials in which excitations equivalent to monopoles can occur. Article 20 September Coupling of plasmonic and optical cavity modes in quasi-three-dimensional plasmonic crystals Quasi-three-dimensional plasmonic crystals have potential uses in miniaturized photonics.
Article 20 September A polysaccharide bioprotonic field-effect transistor The manipulation of electrons forms the basis of modern technology, whereas electrical signalling processes in nature are based on ions and protons.
Article 20 September Late Cretaceous origin of the rice tribe provides evidence for early diversification in Poaceae In this study, fossils from the Late Cretaceous period in India are described and are assigned to the rice tribe based on phylogenetic comparison of morphological traits with modern grasses; these findings suggest that the evolutionary origins of the grass family, Poaceae, occurred earlier than previously thought. Article 13 September Open Access A germanate transparent conductive oxide Transparent conducting oxides are wide bandgap conductors that have found a range of applications in optoelectronic devices.
Article 13 September Open Access Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa Understanding the genetics and physiology of domesticated species is important for crop improvement. Article 13 September p53 and p16 INK4A independent induction of senescence by chromatin-dependent alteration of S-phase progression Cellular senescence is characterized by the cessation of cell growth and the expression of the p16 protein.
Article 13 September Plasmonic substrates for multiplexed protein microarrays with femtomolar sensitivity and broad dynamic range Protein microarrays are useful both in basic research and also in disease monitoring and diagnosis, but their dynamic range is limited. Article 13 September Open Access Information processing using a single dynamical node as complex system The paradigm of reservoir computing shows that, like the human brain, complex networks can perform efficient information processing.
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O'Connor, M. Jollis, M. Schulman, M. Hernandez, M. Tags: heart failure , surgical procedures, operative , comorbidity , patient readmission. Anesthesiology April , Vol. McGregor, M. Lanier, M. Pasternak, M.
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